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A cool menthol switch for gene expression

A synthetic gene circuit uses topical menthol to switch on insulin transgene expression in engineered cells

ETH Zurich researchers have created a synthetic gene circuit activated by topical menthol to switch on gene expression and protein production in engineered cells. In a July Nature Medicine paper, the team used the circuit to trigger insulin production in diabetic mice.

Controlling gene expression with synthetic gene switches could be key to

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