Optimizing base editors to reduce RNA edits

Reducing observed off-target RNA edits by CRISPR-guided base editors

Two Beam co-founders, Keith Joung and David Liu, have separately optimized CRISPR-guided base editors to reduce off-target RNA editing, which, along with unwanted DNA edits, is an emerging problem for the gene engineering tools.

Beam Therapeutics launched in 2018 with a platform of base editors, each

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