White matter matters in Alzheimer’s

An MIT team has identified Alzheimer’s disease-associated changes in gene expression that vary based on cell type, including myelin-related genes, suggesting new pathways that can be explored to treat the disease.

Described in a Nature paper, the Massachusetts Institute of Technology team analyzed single cells, including neurons, oligodendrocytes and microglia, isolated from post-mortem samples to tease out each cell type's gene expression markers of AD...