BioCentury
ARTICLE | Translation in Brief

Accounting for microbial PK

Predicting the microbiome’s contribution to drug metabolism

February 21, 2019 6:27 PM UTC

A Yale University team has created a mathematical model that predicts how the gut microbiome contributes to drug metabolism, offering companies a way to factor microbiome-driven variability between patients into dosing, toxicity and PK studies.

Drug developers have historically ignored the role of the microbiome in breaking down drugs and producing metabolites...

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Yale University