Stabilizing mutant proteins

A team from Novartis Institutes for BioMedical Research (NIBR) and University of British Columbia has hit upon a strategy for treating diseases caused by loss-of-function protein mutations: target allosteric pockets on the mutant proteins to stabilize them.

The team showed the strategy worked on the W580S mutation of MALT1, which causes a form of immunodeficiency, and thinks it can apply to other proteins and diseases...