Mighty microglia

Microglia-specific therapies could be a safer option for brain cancer patients than those that recruit macrophages, according to a paper published this month in Proceedings of the National Academy of Sciences.

While the Stanford University and Colorado University authors had shown in a 2017 Science Translational Medicine paper that inhibiting CD47 could treat brain tumors by inducing phagocytosis, most of the effects were attributed to peripheral macrophages; the role of microglia was unknown. ...