2:35 PM
Jan 09, 2019
 |  BC Innovations  |  Translation in Brief

T cells: Life after exhaustion?

How dysfunctional T cells could aid the development of cancer treatments

Weizmann Institute of Science and Netherlands Cancer Institute (NKI) scientists have shown dysfunctional T cells are not as "exhausted" as previously thought, but display proliferative activity and tumor recognition. In a Cell paper published on Dec. 27, the team wrote further study of this T cell population could help identify new immunomodulatory pathways and better T cell cancer therapies.

Author Anne van der Leun said dysfunctional T cells are typically characterized by loss of effector functions and up-regulation of inhibitory receptors such as PD-1, both of which limit the cells' tumor-killing capacity....

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