Cancer antigens from RNA edits

A team from Immatics Biotechnologies GmbH and University of Texas MD Anderson Cancer Center has shown that cancer antigens generated via post-transcriptional RNA editing could further broaden the target space for immunotherapies.

The study, published in Nature Communications last month, comes on the heels of two papers showing neoantigens can arise as a result of alternative splicing occurring inside tumors, and adds to growing evidence that RNA alterations can serve as sources of cancer antigens (see “Alt-Neoantigens”)...