Reviving NK cells
How targeting TIGIT unleashes the cancer-fighting activity of NK cells
Researchers from the University of Science and Technology of China have identified a key role for TIGIT in NK cell exhaustion that suggests immunotherapies targeting TIGIT may be useful against cancers that have failed to respond to current checkpoint inhibitors.
T cell immunoreceptors with Ig and ITIM domains (TIGIT) is a co-inhibitory checkpoint receptor and an emerging target for immunotherapies designed to overcome tumor-induced immune suppression of T cells. Blocking TIGIT,