ARTICLE | Translation in Brief
Conformist nanobodies
How a new synthetic nanobody platform enables conformation-specific binding
June 28, 2018 10:51 PM UTC
A University of Zurich team in collaboration with Roche has figured out how to make fully synthetic nanobodies that can bind to membrane proteins in specific conformations -- simultaneously opening up new target space for the modality while freeing it from production in animals.
Nanobodies are single-domain antibody fragments derived from camelids. Nanobodies lack a light chain but retain antigen specificity and affinity. Their small size confers the advantage of being able to penetrate tissues that conventional antibodies cannot...