Conformist nanobodies

How a new synthetic nanobody platform enables conformation-specific binding

A University of Zurich team in collaboration with Roche has figured out how to make fully synthetic nanobodies that can bind to membrane proteins in specific conformations -- simultaneously opening up new target space for the modality while freeing it from production in animals.

Nanobodies are single-domain antibody fragments derived from camelids. Nanobodies lack a light

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