ARTICLE | Translation in Brief
Viral variant vaccine
How Singapore team rapidly designed live-attenuated Zika vaccine candidate
April 12, 2018 9:00 PM UTC
A team from Duke-NUS Medical School rapidly developed a live-attenuated Zika vaccine candidate by exploiting genetic errors to identify a strain with high viremia and reduced propagation. The approach could speed development of live vaccines against other viruses, including other flaviviruses and viruses that cause persistent organ infection.
Live-attenuated vaccines provide the longest duration of immunity compared with other types of vaccines, but development is a lengthy process and safety risks associated with the modality must be overcome...
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