Model perpetrators

How a new mathematical model can predict drug-drug interactions

Uppsala University researchers have developed a pharmacodynamic model that predicts synergistic and antagonistic effects of multidrug combinations more accurately than existing models, providing drug developers with a new tool to help select candidate drug combinations before animal testing.

Study author Sebastian Wicha told BioCentury the team’s model, dubbed the general pharmacodynamic interaction model (GPDI), uses data from drugs administered as

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