Beyond PAM

How allele-specific CRISPR-Cas9 editing could treat dominant genetic diseases

Researchers from the Massachusetts Eye and Ear Infirmary (MEEI) and Harvard Medical School have created a CRISPR-Cas9 system that can distinguish between mutant and wild-type alleles, potentially enabling the use of CRISPR-based gene editing to treat a wider range of dominantly inherited diseases than conventional CRISPR systems.

Previous studies in mice have demonstrated the feasibility

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