Perturbation information

L1000 method adds 1.3 million entries to cell perturbation database

Using a low-cost, high throughput transcriptomic method dubbed “L1000,” a Broad Institute team has increased the number of expression profiles in its Connectivity Map database by three orders of magnitude. Connectivity Map catalogs changes in expression patterns induced by a wide range of cellular perturbations and is used to probe on- and off-target effects of compounds, biological consequences of mutations and mechanisms of

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