5:21 PM
Jan 11, 2018
 |  BC Innovations  |  Translation in Brief

In the twenties

CD27 agonists help myeloid cells chow down on cancer

A Cancer Cell study from University of Southampton and Celldex Therapeutics Inc. (NASDAQ:CLDX) researchers suggests combining CD27 agonists with tumor-targeting mAbs could help myeloid cells attack a broad array of cancers. The partners are testing the strategy in the clinic with an anti-CD20 mAb.

Author Sean Lim told BioCentury that while CD27 is primarily known for its co-stimulatory activity on T cells, the target’s therapeutic benefits in this study were mostly due to interactions between mAbs and myeloid cells. “The whole field is focusing on the direct T cell effects of immunostimulatory antibodies, but here, we’ve uncovered a way in which T cell stimulation can benefit direct tumor-targeting antibodies.”

Lim is an associate professor and honorary consultant in hematological oncology at University of Southampton.

“We have been pursuing CD27 combination...

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