Multi-use p53 sensor
A new p53-sensing gene circuit could find many uses in drug discovery
Scientists have made a synthetic gene circuit that senses lost or mutated p53, the tumor suppressor most commonly mutated in human cancers, and can be programmed to trigger a range of outputs, including expression of a cellular suicide switch or a reporter gene. The authors see an application for the circuit in p53-mutant acute myelogenous leukemia (AML), as well as in drug discovery screens and diagnostics.
Wild-type p53 is a transcription factor and