Neutrophil bias

Researchers from the University of Texas Health Science Center have found that IL-27 promotes an anti-inflammatory phenotype in neutrophils that can treat stroke in mice. But safety issues around the recombinant cytokine have the team looking downstream of IL-27 instead, to drug iron metabolism regulators released by the cells.

Neutrophils are important cellular mediators of inflammation recruited into the brain during stroke, where they can adopt pro- or anti-inflammatory phenotypes that exacerbate or ameliorate stroke, respectively. ...