12:10 PM
Aug 31, 2017
 |  BC Innovations  |  Translation in Brief

Mouse model herds

International Mouse Phenotyping Consortium publishes data on 185 disease models

With the publication of its first set of data, the International Mouse Phenotyping Consortium (IMPC) has demonstrated it's making strides toward generating and characterizing the phenotypes of knockout models corresponding to the entire mouse genome -- and the results provide hundreds of new disease models.

IMPC was founded in 2011 on the work of its predecessor organization, the International Knockout Mouse Consortium, which focused on developing mouse embryonic stem cell (ESC) lines. Its 18 member research institutions are funded by the Canadian Institutes of Health Research (CIHR), European Commission, Genome Canada, Medical Research Council (MRC), NIH and Wellcome Trust.

The consortium hit its initial goal of generating 5,000 knockout strains by 2016, and its website says its next target is 20,000 strains (see "Knocks Heard 'Round the World." BioCentury Innovations (Sept. 24, 2015)).

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