BioCentury
ARTICLE | Translation in Brief

TERS talk

Unfolding how cancer cells share ER stress-induced survival signals

June 22, 2017 6:24 PM UTC

A UCSD group has added "transmissible ER stress (TERS)" to the list of cancer's survival strategies. In a study published this month in Science Signaling, the group showed cancer cells undergoing ER stress send soluble signals to their neighbors that help them resist chemotherapy by turning on a mechanism that can relieve ER stress.

The team believes inhibition of the soluble signals or the intracellular pathways they induce could constitute a new therapeutic strategy in cancer...