Unusual suspects

While viral proteins have been considered prime targets for immunotherapy in cancers triggered by viral infections, an NCI study indicates mutated host antigens could be equally or more immunogenic.

The study, published in Science last month, monitored the immune responses of two patients with metastatic cervical cancer caused by human papillomavirus (HPV). Both had been successfully treated via adoptive transfer of tumor-infiltrating lymphocytes (TILs). ...