Infecting cancer

How pathogens can help boost adoptive T cell efficacy against solid tumors

Although adoptive T cell therapies have shown promising clinical efficacy for hematological malignancies, applying the strategy to solid tumors is more challenging because they form an immunosuppressive microenvironment. To overcome that suppression and boost antitumor T cell responses, a U.S. team has developed a new twist on the approach that combines T cells with an injection of bacteria into the tumor.

In a paper published last month in the

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