Culling all flaviviruses

How an ER protein could lead to a single drug for Zika, dengue and more

Washington University researchers have identified a host protein - signal peptidase complex subunit 1 (SPCS1) - that may be required for replication of all flaviviruses, and believe that inhibiting the target could provide a general-purpose treatment for the class, with minimal harm to the host.

In a study published in Nature, a group led by Michael Diamond, a professor of internal

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