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Jun 09, 2016
 |  BC Innovations  |  Translation in Brief

Stopping sepsis

Two new methods could protect against sepsis in adults and neonatal infants

Two teams have uncovered new ways to protect against sepsis in adults and infants by targeting the body's vascular response and inflammatory response, respectively. The findings offer new therapeutic strategies for an indication with few clinical options beyond general care such as antibiotics and intravenous fluids.

The two studies identified new biochemical and mechanistic levers to therapeutically target known players in sepsis.

In Science Translational Medicine, a team led by researchers from the Samsung Advanced Institute of Technology, Institute of Basic Science and the Korea Advanced Institute of Science and Technology identified a mAb that binds angiopoietin 2 (ANG2; ANGPT2) and activates its receptor tyrosine kinase receptor 2 (Tie2), which tamped down vascular inflammation and...

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