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Mar 17, 2016
 |  BC Innovations  |  Translation in Brief

Clasped together

Highly specific detection of epigenetic marks via antigen-clasping antibodies

A team at the University of Chicago has identified two antibodies that recognize an epigenetic marker via a new, highly specific "antigen-clasping" modality. The authors think the unusual antibodies could be a shot in the arm for epigenetics-based diagnostics, an area that's been hamstrung by the difficulty of creating antibodies able to differentiate one epigenetic modification from another.

Shohei Koide told BioCentury his team wasn't looking for a new binding modality when it started using directed evolution to find antibodies targeting trimethylated histone H3.

"We were purely interested in achieving extreme levels of specificity, in this case for histone modifications," he said.

Koide is a professor of biochemistry and molecular biophysics at the university.

In the study, published last month in...

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