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Quantitative boost for CSHL

The Simons Foundation has donated $50 million to Cold Spring Harbor Laboratory to establish the Simons Center for Quantitative Biology. The center's goal is to develop quantitative approaches that can maximize the utility of high-content imaging and genomic data produced by the laboratory and its partners.

The center will focus on creating computational methods to mine complex genomic and imaging data related to cancer and neurological diseases including autism, schizophrenia and bipolar disorder.

Bruce Stillman, president and CEO of Cold Spring Harbor Laboratory (CSHL), told SciBX that high throughput studies investigating changes in neuronal connectivity need new methods of data analysis. "The sheer quantity of imaging data has made it clear that more capable algorithms and statistical methods are required to extract the full amount of buried information," he said.

In addition, he said that ongoing work at CSHL's genome center on patients with cancer, schizophrenia or bipolar disorder have generated massive genomic data sets that require an enhanced analytical tool set to reveal their information in full depth.

"These data collections are steadily growing due to the fact that conventional and single-cell genome and imaging analyses have now become major research strategies at CSHL. Multiple complex data sets need to be meaningfully integrated to identify biological and pathological principles," said Stillman.

To run the center, CSHL recruited Adam Siepel, who was previously an associate professor at Cornell University with a background in comparative genome biology

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