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11:56 AM, Aug 16, 2018  |  BC Innovations | Translation in Brief

Selective hearing

A pair of Cell papers published this month used single-cell RNA sequencing to molecularly define three subtypes of auditory neurons, opening up new therapeutic targets for restoring synaptic connections in hearing loss disorders. Researchers from Decibel...
9:31 AM, Aug 15, 2018  |  BC Innovations | Translation in Brief

Not your typical vaccine

In a July paper in the Proceedings of the National Academy of Sciences, University of Mississippi Medical Center researchers and colleagues identified conserved proteins in non-typeable Haemophilius influenzae that activate T cell responses to the...
9:34 AM, Aug 14, 2018  |  BC Innovations | Translation in Brief

Primate predictions

A team at Illumina Inc. (NASDAQ:ILMN) has developed an AI algorithm that will help identify pathogenic mutations from genome sequencing analyses by including non-human primate data in the training data set, and the approach could...
12:42 PM, Aug 09, 2018  |  BC Innovations | Translation in Brief

Buggy Bug World

A data dive into the TwinsUK registry based at King’s College London has revealed new associations between gut microbiota and disease, including some outside the usual suspects, like urinary incontinence. The study found not just...
5:38 PM, Aug 08, 2018  |  BC Innovations | Translation in Brief

Identifying the ubiquitinators

A team at University of Dundee and Newcastle University has developed a mass spectrometry-based screening platform to identify ubiquitin ligases and compounds that modulate them. The approach uses the uptake of ubiquitin by enzymes rather...
4:05 PM, Aug 01, 2018  |  BC Innovations | Translation in Brief

New Therapeutic Targets and Biomarkers: July 2018

New Therapeutic Targets and Biomarkers: July 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2018. Therapeutic targets are defined as any protein, gene or other molecule...
2:18 PM, Jul 31, 2018  |  BC Innovations | Translation in Brief

ATAC of the DREADDs

Scientists from the California Institute of Technology have combined ultrasound waves with gene and drug therapies to selectively and non-invasively control neural circuits. The approach could be used to treat neurologic and psychiatric diseases and...
2:15 PM, Jul 31, 2018  |  BC Innovations | Translation in Brief

Satellite damage

Researchers at the Salk Institute for Biological Studies have figured out how RNA transcribed from satellite DNA repeats could promote tumorigenesis by hindering DNA repair, highlighting a potential new target for cancer. Satellite RNAs are a...
11:22 AM, Jul 26, 2018  |  BC Innovations | Translation in Brief

A plasticity problem

New research from the University of Bordeaux suggests the synaptic pathology underlying Alzheimer’s disease is driven by aberrant activation of CAMK2 by β-amyloid oligomers. The findings may point to the missing link in how β-amyloid...
9:04 AM, Jul 26, 2018  |  BC Innovations | Translation in Brief

Closing the loop

A University College London team has developed a chemogenetically activated gene therapy for refractory focal epilepsy that inhibits seizure-generating neurons in response to increased extracellular glutamate levels, a hallmark of seizures. The approach could provide...

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