BioCentury
ARTICLE | Tools & Techniques

Master of autism

How a CPEB4 isoform imbalance could be the key to modeling polygenic autism

August 30, 2018 5:21 PM UTC

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way of thinking about how to model polygenic diseases.

Like many neurological conditions, the vast majority of autism cases are idiopathic, not driven by a single mutation but by the complex interplay of small genetic risk factors as well as environmental influences. ...