BioCentury
ARTICLE | Tools & Techniques

Superhuman mice

May 1, 2014 7:00 AM UTC

The paradox of current mouse-based antibody platforms is that the Ig gene manipulations used to generate the mice can limit the animals' ability to produce robust antibody responses. Kymab Ltd. and Regeneron Pharmaceuticals Inc. have now published details about how their newest mouse platforms circumvent these issues and improve antibody diversity and affinity.1-3

Past approaches to engineering mice to develop human antibodies relied on the sequential random insertion of human Ig genes and partial or total elimination of the equivalent mouse Ig genes...