BioCentury
ARTICLE | Tools & Techniques

Plan B for anti-miRNA

December 12, 2013 8:00 AM UTC

Formulating and delivering therapeutic anti-microRNAs has been a big challenge in the burgeoning anti-miRNA space. Now, a University of California team has proof of concept for a surprisingly simple way to deliver these molecules into the bloodstream using engineered B cells.1

The UCSD group, led by Professor of Medicine Maurizio Zanetti, used murine B cells transfected with an RNA-encoding construct to knock down expression of an endogenous miRNA in T cells, which work closely with B cells during immune activity (see "Anti-miRNA delivery by B cells")...