BioCentury
ARTICLE | Tools & Techniques

Pulmonary edema on a chip

December 13, 2012 8:00 AM UTC

Researchers at the Harvard University have described the first disease model to emerge from the institute's organ-on-a-chip microfluidic device technology.1,2 The model of pulmonary edema could be better than culture models at predicting whether therapeutics will translate to humans.

The team already has used the lung-on-a-chip model in proof-of-concept studies to test potential pulmonary edema therapeutic candidates including GlaxoSmithKline plc's GSK2193874, an inhibitor of transient receptor potential vanilloid 4 (TRPV4; VRL2),3 and wants to expand the use of the chip to model multiple lung diseases...