Fusion factor
Researchers at Massachusetts General Hospital have developed self-assembling nanoparticlesconsisting ofa fusion protein containing anelastin-like peptide and keratinocyte growth factor, two key components of skin remodeling.1 The nanoparticles could be a therapeutic option in indications like chronic wound healing, and the MGH team plans to evaluate similar elastin-like peptide-based fusion protein combinations for this indication.
Previous studies have suggested that keratinocyte growth factor (KGF) could help accelerate wound healing.2Swedish Orphan Biovitrum AB already markets a recombinant human KGF, Kepivance palifermin, to treat severe oral mucositis. The company acquired the biologic from Amgen Inc. in 2008. Kepivance is delivered via i.v. infusion...