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Cell-free joint regeneration

Columbia University Medical Center researchers have identified a cell-free tissue-regeneration strategy that not only helps replace lost bone but also regenerates cartilage, a feat that has stymied previous joint replacement efforts.1

Treatments for the structural breakdown of bone and cartilage that occurs in osteoarthritis include total joint replacement with a metallic or synthetic prosthetic. The devices do a good job of mimicking joint function, but wear between the patient's bone and the device can lead to loosening of the prosthetic, infection and failure after 10-15 years.2

Tissue regeneration using stem or progenitor cells represents an alternative to the devices but has its own risks, such as pathogen transmission, immune rejection and tumorigenesis. Other cell delivery challenges include preserving, maintaining and transporting the live cells,

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