BioCentury
ARTICLE | Tools & Techniques

Predicting allograft tolerance

June 10, 2010 7:00 AM UTC

Based on an analysis of two groups of kidney transplant patients able to thrive without immunosuppressants, consortia in Europe and the U.S. have independently identified immature B cells as markers that could help pinpoint transplant patients who may not need immunosuppressants. Miltenyi Biotec GmbH and Pangaea Biotech S.A. have options to develop diagnostics based on the discoveries, which were reported in back-to-back papers in The Journal of Clinical Investigation. 1,2

The consortia-the EU-based Indices of Tolerance,the EU-basedReprogramming the Immune System for the Establishment of Toleranceand the U.S.-based Immune Tolerance Network-were searching for clues about why some patients don't reject transplants...