BioCentury
ARTICLE | Tools & Techniques

Smooth Grafts Ahead

September 4, 2008 7:00 AM UTC

Researchers at the Georgia Institute of Technology have developed an approach to address a major problem with synthetic tissue grafts: poor integration with host tissue. The group used polymer-immobilized retroviruses to control cell differentiationand distribution within a graft's scaffold. The strategy potentially can be used to create interfaces between graft and host that mimic the natural transitions in musculoskeletal tissues, thus encouraging host cells to migrate into and take hold of the graft.1

Companies in the regenerative medicine space now want to see additional in vivo studies on the long-term safety and stability of grafts produced with the approach...