BioCentury
ARTICLE | Tools & Techniques

Surrogate Antibodies

August 14, 2008 7:00 AM UTC

A study by researchers at The Scripps Research Instituteand Sea Lane Biotechnologies LLC describes the generation of Surrobodies, or antibody-like molecules with high antigen-binding affinities, using phage display and combinatorial methods.1 The authors think the unique structural features of Surrobodies could produce molecules that have greater diversity and more functionality-perhaps including intracellular targeting-than antibodies.

The research, led by Richard Lerner, president and professor of chemistry and immunochemistry at Scripps, and Ramesh Bhatt, VP of research at Sea Lane, was published in the Proceedings of the National Academy of Sciences. ...