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363 items
3:04 PM, Jul 19, 2018  |  BC Innovations | Tools & Techniques

Immunotherapy Matchmaking

MD Anderson Cancer Center is using its access to patient samples to inject more rationality into decisions about which therapies should be paired with checkpoint inhibitors, and how to optimize the combos. The goal is...
6:11 PM, Jun 28, 2018  |  BC Innovations | Tools & Techniques

QT replacement plan

FDA has completed validation of a preclinical assay system that could replace clinical QT testing, a move it hopes will lower development costs and reduce false alarms of arrhythmia risk. The question for drug developers...
4:27 PM, Jun 14, 2018  |  BC Innovations | Tools & Techniques

Imaging immunotherapy

Stanford University researchers have made an imaging agent that detects activated T cells and could predict whether a patient will respond to immunotherapy within days of treatment. Typically, it takes weeks to months to determine...
6:36 PM, Jun 07, 2018  |  BC Innovations | Tools & Techniques

NK cell check-in

Until recently, there’s been scarce overlap between the NK cell field and the world of checkpoint inhibitors, with the former focused on cell therapies to kill tumor cells directly and the latter on relieving immune...
2:46 PM, May 31, 2018  |  BC Innovations | Tools & Techniques

Bundled inheritance

Two new studies showcase how researchers are gleaning more from GWAS by combining risk factors rather than looking at the risks from individual mutations. The results could add numbers to the contribution of nature vs....
5:00 PM, Apr 19, 2018  |  BC Innovations | Tools & Techniques

Structured outlook

A Cell study capturing hundreds of E. coli mRNA structures makes the case that complex, functionally relevant RNA structures are the rule, not the exception, and builds confidence that mRNAs -- once widely considered undruggable...
4:36 PM, Mar 29, 2018  |  BC Innovations | Tools & Techniques

Cutting-edge diagnostics

Following the splash that CRISPR has made in the world of therapeutics, academics are expanding the tool kit of Cas enzymes and finding new uses in diagnostics. Early hints suggest the technology could become competitive,...
11:52 AM, Mar 15, 2018  |  BC Innovations | Tools & Techniques

Shared burden

Having learned their lesson with PD-L1, companies are collaborating on assay standards for tumor mutation burden -- a likely contender for the next major biomarker in immuno-oncology. A Friends of Cancer Research-led consortium of pharmas...
6:57 PM, Feb 01, 2018  |  BC Innovations | Tools & Techniques

Cutting a new path

As gene editing starts to make headway, its first indications are informed by the path laid by gene therapies and other nucleic acid modalities. But drug developers think editing is poised to move far beyond...
7:28 PM, Jan 18, 2018  |  BC Innovations | Tools & Techniques

Synthetic expressions

Bringing synthetic biology to transcriptional regulation could catalyze a new generation of gene therapies that are more tunable, disease-specific and easy to deliver than the products dominating the field. The new constructs include synthetic promoters that...