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366 items
6:21 PM, Sep 20, 2018  |  BC Innovations | Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
10:21 AM, Aug 30, 2018  |  BC Innovations | Tools & Techniques

Master of autism

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way...
3:15 PM, Aug 02, 2018  |  BC Innovations | Tools & Techniques

Model firsts

By combining disparate data into coherent mechanistic models, quantitative systems pharmacology is becoming a key tool for picking the right dose for first-in-human trials and other early make-or-break decisions. Advocates see it as part of...
3:04 PM, Jul 19, 2018  |  BC Innovations | Tools & Techniques

Immunotherapy Matchmaking

MD Anderson Cancer Center is using its access to patient samples to inject more rationality into decisions about which therapies should be paired with checkpoint inhibitors, and how to optimize the combos. The goal is...
6:11 PM, Jun 28, 2018  |  BC Innovations | Tools & Techniques

QT replacement plan

FDA has completed validation of a preclinical assay system that could replace clinical QT testing, a move it hopes will lower development costs and reduce false alarms of arrhythmia risk. The question for drug developers...
4:27 PM, Jun 14, 2018  |  BC Innovations | Tools & Techniques

Imaging immunotherapy

Stanford University researchers have made an imaging agent that detects activated T cells and could predict whether a patient will respond to immunotherapy within days of treatment. Typically, it takes weeks to months to determine...
6:36 PM, Jun 07, 2018  |  BC Innovations | Tools & Techniques

NK cell check-in

Until recently, there’s been scarce overlap between the NK cell field and the world of checkpoint inhibitors, with the former focused on cell therapies to kill tumor cells directly and the latter on relieving immune...
2:46 PM, May 31, 2018  |  BC Innovations | Tools & Techniques

Bundled inheritance

Two new studies showcase how researchers are gleaning more from GWAS by combining risk factors rather than looking at the risks from individual mutations. The results could add numbers to the contribution of nature vs....
5:00 PM, Apr 19, 2018  |  BC Innovations | Tools & Techniques

Structured outlook

A Cell study capturing hundreds of E. coli mRNA structures makes the case that complex, functionally relevant RNA structures are the rule, not the exception, and builds confidence that mRNAs -- once widely considered undruggable...
4:36 PM, Mar 29, 2018  |  BC Innovations | Tools & Techniques

Cutting-edge diagnostics

Following the splash that CRISPR has made in the world of therapeutics, academics are expanding the tool kit of Cas enzymes and finding new uses in diagnostics. Early hints suggest the technology could become competitive,...