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2:43 PM, Nov 15, 2018  |  BC Innovations | Tools & Techniques

Benchtop manufacturing gets smaller

MIT scientists continue to break new ground in benchtop manufacturing systems for biologics. Published in Nature Biotechnology last month, the latest advance from the institute centered on an automated, closed system capable of producing clinical-grade...
8:47 PM, Nov 08, 2018  |  BC Innovations | Tools & Techniques

HitGen’s DNA for small molecules

With more than 60 partnerships under its belt, HitGen Ltd. has become a major gateway for companies to access DNA-encoded library technology -- a high efficiency form of combinatorial chemistry that upstages high throughput screening....
5:05 PM, Oct 25, 2018  |  BC Innovations | Tools & Techniques

Deconstructing the rule of five

The concept of drug-like properties has come under fire from a Novartis AG study that found the last 20 years of drugs have not conformed to the rule of five. Showing the rule’s principles have...
5:36 PM, Oct 18, 2018  |  BC Innovations | Tools & Techniques

Allogeneic CARs on the horizon

With the first generation of autologous, personalized CAR T cell therapies on the market, the field is turning to allogeneic technologies to provide better scale and lower costs. But drug makers are learning that as...
3:33 PM, Oct 04, 2018  |  BC Innovations | Tools & Techniques

No crisp upper hand in CRISPR

While the most recent ruling in the ongoing CRISPR IP battle maintained the Broad Institute’s dominant patent position in the U.S., University of California Berkeley’s dominant position in Europe, coupled with the looming possibility of...
3:01 PM, Oct 04, 2018  |  BC Innovations | Tools & Techniques

Lilly: academic about manufacturing

As Eli Lilly and Co. moves toward continuous manufacturing, the pharma is deepening ties with two academic centers to meet an array of engineering challenges. Through partnerships with Carnegie Mellon University, and the U.K.’s Imperial...
5:07 PM, Sep 27, 2018  |  BC Innovations | Tools & Techniques

Deconstructing tox in immuno-oncology

The best route to improving preclinical toxicity in immunotherapies could lie in reverse translation, feeding clinical data back into the preclinical space to inform model development, rather than trying to guess a priori what the...
6:21 PM, Sep 20, 2018  |  BC Innovations | Tools & Techniques

Precision for pancreatic cancer

Real-time sequencing and organoid-based screens in pancreatic cancer could place new targets and biomarkers in the hands of drug developers looking for ways to side-step KRAS, a gene mutated in 90% of patients. Because KRAS...
10:21 AM, Aug 30, 2018  |  BC Innovations | Tools & Techniques

Master of autism

The discovery of a master regulator of autism risk genes has yielded the first mouse model of the form of the condition that accounts for about 90% of patients, and could spark a new way...
3:15 PM, Aug 02, 2018  |  BC Innovations | Tools & Techniques

Model firsts

By combining disparate data into coherent mechanistic models, quantitative systems pharmacology is becoming a key tool for picking the right dose for first-in-human trials and other early make-or-break decisions. Advocates see it as part of...

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