New cereblon substrates linked to thalidomide teratogenicity

New drug-dependent cereblon substrates linked to thalidomide teratogenicity

A Celgene-funded study from Tokyo Medical University and the University of Milan has identified two new thalidomide-dependent CRBN substrates that could be applied to screens for new, safer thalidomide derivatives.

Thalidomide and its analogs, collectively called imids, cause a range of teratogenic effects, including limb deformities, ear malformation and heart defects.

Read the full 516 word article

Trial Subscription

Get a two-week free trial subscription to BioCentury

SIGN UP

Article Purchase

This article may not be distributed to non-subscribers
More Info >PURCHASE