ARTICLE | Targets & Mechanisms
The polyQ diet
How polyQ tracts block autophagy in neurodegenerative diseases
May 4, 2017 10:49 PM UTC
Expanded polyglutamine repeats at the ends of disease-causing proteins are well known to promote formation of aggregates that drive various neurodegenerative disorders. A new study from the University of Cambridge shows those repeats have a second pathological role -- preventing elimination of the aggregates by blocking autophagy.
The results reinforce the emerging notion that boosting autophagy could be a general strategy for combating neurodegenerative diseases involving aggregated proteins. ...
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