BioCentury
ARTICLE | Targets & Mechanisms

Bone appétit!

How a bone hormone could help treat obesity

March 16, 2017 10:30 PM UTC

Last week’s Nature publication of a hormone secreted by bone that suppresses appetite and can curb weight gain not only adds to the emerging picture of bone as a player in the endocrine system but establishes a bone-brain axis as a new way to treat obesity.

Osteoblasts - the cells that make bone - are now recognized as major players in bone biology, with the ability to both make and release hormones. They are thought to play a role in metabolism because they secrete osteocalcin, which promotes energy expenditure, insulin secretion and glucose homeostasis, and FGF23, which regulates phosphate metabolism in the kidney...

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Columbia University

BCIQ Target Profiles

Lipocalin (NGAL) (LCN2)