BioCentury
ARTICLE | Targets & Mechanisms

Death metal

The newest cell death pathway ferroptosis could be ripe for investment

January 27, 2017 1:21 AM UTC

The findings in two high profile papers on ferroptosis could be the nudge the fledgling field needs to gain the attention of drug developers. The process is the latest cell death pathway to offer up new targets, with roles in a range of indications, most notably neurodegeneration and cancer.

Unlike the better known pathways apoptosis and necroptosis, ferroptosis depends on iron and involves no caspases. In particular, it has its own genetic and morphological trademark and biology driven by redox chemistry. ...