ARTICLE | Targets & Mechanisms
Joint attack
Targeting overactive fibroblasts could prevent joint damage in RA
May 28, 2015 7:00 AM UTC
A newly discovered pathway that causes joint erosion in rheumatoid arthritis could lead to a new class of therapies that act locally in cells of the synovial lining and avoid the drawbacks of immunosuppressants.
The pathway was identified by a group at the La Jolla Institute for Allergy & Immunology, which found that activation of a receptor phosphatase on synovial fibroblasts reduced the cells' pathological activity. ...