Adipsin meets beta cells

The long-standing mystery of how adipsin regulates metabolism has been solved by a Harvard-led team that has shown the enzyme can increase insulin secretion by generating the peptide complement 3a . ¹ Its therapeutic potential may hinge on showing that the effect persists with chronic dosing and does not trigger inflammationor other unwanted side effects.

The team is now planning to test recombinant adipsin in long-term safety and efficacy studies in mouse models of diabetes...