Mired in miR-25

Preclinical data showing that microRNA-25 inhibition can help treat heart failure directly contradict a 2013 paper suggesting that decreased levels of the miRNA provoke the condition.^1,2 Although the new study shows that blocking microRNA-25 restores levels of the SERCA2A calcium uptake channel-and thus improves cardiac contractility-the discrepancy with the earlier result needs resolving before a microRNA-25-based therapy can be developed.

The two studies zeroed in on microRNA-25 (miR-25) by different routes...