HER2's outside help

An international team has found that neurokinin 1 substance P receptor, a known player in nausea, pain and inflammation, enhances HER2 signaling in breast cancer.¹ The findings argue for combining antagonists against both receptors to treat cancer.

HER2 (EGFR2; ErbB2; neu) is a receptor tyrosine kinase (RTK) that promotes aggressive tumor growth in about 30% of breast cancers...