CRACking pancreatitis

The handful of companies pursuing CRAC inhibitors for immunological disorders have a new indication to consider-acute pancreatitis. New findings from Cardiff University¹ show that the target plays a central role in the painful and potentially life-threatening condition for which there are no FDA-approved, disease-modifying therapies.

Binge drinking can trigger acute pancreatitis, in which excessive release of pancreatic enzymes leads to pain, inflammation and damage to pancreatic tissue...