Islet transplants find the adrenal gland
German and U.S. researchers have shown that transplantation into the adrenal gland of islet cells preconditioned with an improved peptide agonist of growth hormone-releasing hormone may help normalize glucose levels in diabetic mice better than existing islet transplantation protocols.1 The agonist has been licensed to Biscayne Pharmaceuticals Inc. for all indications, and the benefits of the intra-adrenal transplantation protocol will next be confirmed in large animal models.
Although transplantation of pancreatic islet cells has the potential to permanently correct dysfunctional insulin production and treat
type 1 diabetes, current procedures require long-term immunosuppressive treatment, and progressive loss of islet functionality poses a big challenge.
Besides destructive autoimmunity, additional causes of