Targeting inflammation in AD

German researchers have implicated the inflammasome, an intracellular sensor of proinflammatory signaling, as a key player in Alzheimer's disease.¹ The findings provide additional evidence that Alzheimer's disease could be treated with anti-inflammatory agents that act upstream of b-amyloid deposition.

The accumulation of b-amyloid (Ab) is thought to underlie the neurodegeneration at the heart of AD, and as a result most efforts to treat the disease have focused on directly blocking Ab production or the accumulation of Ab plaques...