BioCentury
ARTICLE | Targets & Mechanisms

Solving triptolide

November 29, 2012 8:00 AM UTC

University of Minnesota researchers have developed a water-soluble prodrug of the poorly soluble cancer therapeutic triptolide that could give a second life to the plant-derived compound.1 Minneamrita Therapeutics LLC holds a license to the new molecule and plans to start a Phase I trial within six months.

Triptolide is a diterpenoid triepoxide derived from the traditional Chinese medicine plant Tripterygium wilfordii...