Still un-sirtuin

Researchers at the NIH have proposed a new mechanism to explain the beneficial metabolic effects of resveratrol, a polyphenol compound from red wine thought by many to act primarily on sirtuin 1. The NIH team suggests resveratrol works by inhibiting phosphodiesterase-4, an enzyme that sits far upstream of sirtuin 1 and affects a signaling pathway that leads to increased energy utilization.¹

The findings could provide repurposing opportunities for the plethora of phosphodiesterase-4 (PDE-4) inhibitors on the market or in the clinic, primarily for pulmonary indications...